About

Dr. Isaac Manke is an independent director of Addex and a member of the Audit Committee. He has more than 15 years of experience in the life science industry as an investor, research analyst, consultant and scientist. He was a General Partner at Acorn Bioventures for over five years, investing in small-cap public and private biotechnology companies, and previously spent 11 years at New Leaf Venture Partners, where he led public investment activities and managed the NLV Biopharma Opportunities Funds from 2014 to 2019. He is a director of OnKure Therapeutics (Nasdaq: OKUR) and Q32 Bio (Nasdaq: QTTB) and has served on the boards of True North Therapeutics (acquired by Bioverativ) and Karos Pharmaceuticals. He received a B.A. in Biology and a B.A. in Chemistry from Minnesota State University (Moorhead) and a Ph.D. in Biophysical Chemistry and Molecular Structure from MIT.

Roles

Addex Therapeutics Ltd.
Director (Independent) · Current role
Present
Acorn Bioventures
General Partner · Over 5 years; small-cap biotech investing
New Leaf Venture Partners
Partner (public investments; NLV Biopharma Opportunities Funds 2014-2019) · 11 years
Sanford C. Bernstein / Deutsche Bank
Biotechnology equity research
Health Advances
Senior Analyst

External Roles

OnKure Therapeutics (Nasdaq: OKUR)
Director
present
Q32 Bio (Nasdaq: QTTB)
Director
present

Director Compensation

FY 2025
Fixed compensation
CHF 16,355
ComponentFixed annual Board compensation, FY2025 (CHF)
Variable cash (attendance)
CHF 16,355
ComponentVariable cash based on Board-meeting attendance, FY2025
Total
CHF 32,710
BasisNo equity incentive units were granted to Board members in 2025.

Also at Addex Therapeutics Ltd.

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